Nature Immunology Cotents: December 2007
11/16/2007 | Георгій
Ось, отримав такe собі на "мило." Можна підписатися на ці "алeрти," здається, задурно. 
Max Planck Society and Nature Immunology present: Determinism and plasticity of T lymphocytes
A Ringberg Colloquium
February 10-13, 2008 * Tegernsee, Germany
The aim is to stimulate conceptual breakthroughs leading to advancement in the fields of chronic inflammation and control of infection mediated by T lymphocytes.
Attendees are chosen by invitation or application.
Application deadline- December 10
To apply visit: www.nature.com/natureconferences/ringberg2008
Sponsored by: Schering-Plough
Editorial Top
Global scourge p1267
Diverse measures are needed to combat the detrimental effects of poverty on children in developing and developed nations.
doi:10.1038/ni1207-1267
Full Text | PDF
Essay Top
Bacterial cell walls, innate immunity and immunoadjuvants pp1269 - 1271
Jack Strominger recounts his seminal work and contributions to understanding bacterial cell wall components, and thus how penicillin functions, and the implications of these discoveries for immunology.
Jack L Strominger
doi:10.1038/ni1207-1269
Full Text | PDF
Commentaries Top
Science, medicine and research in the developing world: a perspective pp1273 - 1276
As part of the Global Theme Issue on Poverty and Human Development, Frances Gotch and Jill Gilmour describe the development of laboratory capacity to support HIV vaccine trials as a model for technology transfer in the developing world.
Frances Gotch and Jill Gilmour
doi:10.1038/ni1531
Full Text | PDF
Global health science: a threat and an opportunity for collaborative clinical science pp1277 - 1279
We will never have a better opportunity to improve public health globally. The question is whether we are shrewd enough, bold enough, and committed enough to make it happen.
Jeremy Farrar
doi:10.1038/ni1532
Full Text | PDF
News and Views Top
IL-10 or not IL-10: that is the question pp1281 - 1283
Four new papers focused on how interleukin 10-producing cells are induced have led to some unexpected and intriguing observations on the nature of interleukin 17-producing T helper cells.
Dragana Jankovic and Giorgio Trinchieri
doi:10.1038/ni1207-1281
Full Text | PDF
See also: Article by Stumhofer et al. | Article by Fitzgerald et al. | Article by Awasthi et al. | Article by McGeachy et al.
CCR5 and its ligands: a new axis of evil? pp1283 - 1285
Many additional effects in HIV pathogenesis are now described for the chemokine receptor CCR5, long recognized as an important coreceptor for HIV, and its ligand CCL3L1.
Michael M Lederman and Scott F Sieg
doi:10.1038/ni1207-1283
Full Text | PDF
See also: Article by Dolan et al.
Competition for cytokines: Treg cells take all pp1285 - 1287
Thymus-derived regulatory T cells are thought to suppress target cells by either a cell contact-dependent mechanism or the production of inhibitory cytokines. A new study suggests a third strategy of apoptosis induced by the consumption of interleukin 2 and other T cell growth factors by regulatory T cells.
Alexander Scheffold, Kenneth M Murphy and Thomas Höfer
doi:10.1038/ni1207-1285
Full Text | PDF
See also: Article by Pandiyan et al.
Macrophage tolerance: CD47-SIRP-α-mediated signals matter
pp1287 - 1289
Inhibition of phagocyte activity depends on the ligation of SIRP-α by CD47. New findings show that Sirpa polymorphisms influence the engraftment and tolerance of xenogeneic transplants in NOD-SCID mice.
Hitoshi Takizawa and Markus G Manz
doi:10.1038/ni1207-1287
Full Text | PDF
See also: Article by Takenaka et al.
Unexpected partnership between IL-15 and DAP10 pp1289 - 1291
Interleukin 15 (IL-15) is essential for natural killer (NK) cell development and function, and the adaptor DAP10 transmits important signals in NK cells. New work shows that IL-15 and DAP10 cross regulate each other.
Francesco Colucci
doi:10.1038/ni1207-1289
Full Text | PDF
See also: Article by Horng et al.
Research Highlights Top
Research Highlights p1293
doi:10.1038/ni1207-1293
Full Text | PDF
Review Top
Finding a way out: lymphocyte egress from lymphoid organs
pp1295 - 1301
Susan R Schwab and Jason G Cyster
doi:10.1038/ni1545
Abstract | Full Text | PDF
Articles Top
'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage pp1303 - 1312
Nicole C Kaneider, Andrew J Leger, Anika Agarwal, Nga Nguyen, George Perides, Claudia Derian, Lidija Covic and Athan Kuliopulos
doi:10.1038/ni1525
Abstract | Full Text | PDF
Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells pp1313 - 1323
Katsuto Takenaka, Tatiana K Prasolava, Jean C Y Wang, Steven M Mortin-Toth, Sam Khalouei, Olga I Gan, John E Dick and Jayne S Danska
doi:10.1038/ni1527
Abstract | Full Text | PDF
See also: News and Views by Takizawa & Manz
CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms pp1324 - 1336
Matthew J Dolan, Hemant Kulkarni, Jose F Camargo, Weijing He, Alison Smith, Juan-Manuel Anaya, Toshiyuki Miura, Frederick M Hecht, Manju Mamtani, Florencia Pereyra, Vincent Marconi, Andrea Mangano, Luisa Sen, Rosa Bologna, Robert A Clark, Stephanie A Anderson, Judith Delmar, Robert J O'Connell, Andrew Lloyd, Jeffrey Martin, Seema S Ahuja, Brian K Agan, Bruce D Walker, Steven G Deeks and Sunil K Ahuja
doi:10.1038/ni1521
Abstract | Full Text | PDF
See also: News and Views by Lederman & Sieg
Natural killer cell trafficking in vivo requires a dedicated sphingosine
1-phosphate receptor pp1337 - 1344
Thierry Walzer, Laura Chiossone, Julie Chaix, Andrew Calver, Claude Carozzo, Laure Garrigue-Antar, Yannick Jacques, Myriam Baratin, Elena Tomasello and Eric Vivier
doi:10.1038/ni1523
Abstract | Full Text | PDF
NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway pp1345 - 1352
Tiffany Horng, Jelena S Bezbradica and Ruslan Medzhitov
doi:10.1038/ni1524
Abstract | Full Text | PDF
See also: News and Views by Colucci
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells pp1353 - 1362
Pushpa Pandiyan, Lixin Zheng, Satoru Ishihara, Jennifer Reed and Michael J Lenardo
doi:10.1038/ni1536
Abstract | Full Text | PDF
See also: News and Views by Scheffold et al.
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10 pp1363 - 1371
Jason S Stumhofer, Jonathan S Silver, Arian Laurence, Paige M Porrett, Tajie H Harris, Laurence A Turka, Matthias Ernst, Christiaan J M Saris, John J O'Shea and Christopher A Hunter
doi:10.1038/ni1537
Abstract | Full Text | PDF
See also: News and Views by Jankovic & Trinchieri | Article by Fitzgerald et al. | Article by Awasthi et al. | Article by McGeachy et al.
Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
pp1372 - 1379
Denise C Fitzgerald, Guang-Xian Zhang, Mohamed El-Behi, Zoë Fonseca-Kelly, Hongmei Li, Shuo Yu, Christiaan J Saris, Bruno Gran, Bogoljub Ciric and Abdolmohamad Rostami
doi:10.1038/ni1540
Abstract | Full Text | PDF
See also: News and Views by Jankovic & Trinchieri | Article by Stumhofer et al. | Article by Awasthi et al. | Article by McGeachy et al.
A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells pp1380 - 1389
Amit Awasthi, Yijun Carrier, Jean P S Peron, Estelle Bettelli, Masahito Kamanaka, Richard A Flavell, Vijay K Kuchroo, Mohamed Oukka and Howard L Weiner
doi:10.1038/ni1541
Abstract | Full Text | PDF
See also: News and Views by Jankovic & Trinchieri | Article by Stumhofer et al. | Article by Fitzgerald et al. | Article by McGeachy et al.
TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell-mediated pathology pp1390 - 1397
Mandy J McGeachy, Kristian S Bak-Jensen, Yi Chen, Cristina M Tato, Wendy Blumenschein, Terrill McClanahan and Daniel J Cua
doi:10.1038/ni1539
Abstract | Full Text | PDF
See also: News and Views by Jankovic & Trinchieri | Article by Stumhofer et al. | Article by Fitzgerald et al. | Article by Awasthi et al.
Erratum Top
Erratum: Immune responses to commensal and environmental microbes p1398
Eric G Pamer
doi:10.1038/ni1207-1398a
Full Text | PDF
Corrigendum Top
Corrigendum: Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-γ p1398
Jamie R Schoenborn, Michael O Dorschner, Masayuki Sekimata, Deanna M Santer, Maria Shnyreva, David R Fitzpatrick, John A Stamatoyannopoulos and Christopher B Wilson
doi:10.1038/ni1207-1398b
Full Text | PDF
Max Planck Society and Nature Immunology present: Determinism and plasticity of T lymphocytes
A Ringberg Colloquium
February 10-13, 2008 * Tegernsee, Germany
The aim is to stimulate conceptual breakthroughs leading to advancement in the fields of chronic inflammation and control of infection mediated by T lymphocytes.
Attendees are chosen by invitation or application.
Application deadline- December 10
To apply visit: www.nature.com/natureconferences/ringberg2008
Sponsored by: Schering-Plough
Editorial Top
Global scourge p1267
Diverse measures are needed to combat the detrimental effects of poverty on children in developing and developed nations.
doi:10.1038/ni1207-1267
Full Text | PDF
Essay Top
Bacterial cell walls, innate immunity and immunoadjuvants pp1269 - 1271
Jack Strominger recounts his seminal work and contributions to understanding bacterial cell wall components, and thus how penicillin functions, and the implications of these discoveries for immunology.
Jack L Strominger
doi:10.1038/ni1207-1269
Full Text | PDF
Commentaries Top
Science, medicine and research in the developing world: a perspective pp1273 - 1276
As part of the Global Theme Issue on Poverty and Human Development, Frances Gotch and Jill Gilmour describe the development of laboratory capacity to support HIV vaccine trials as a model for technology transfer in the developing world.
Frances Gotch and Jill Gilmour
doi:10.1038/ni1531
Full Text | PDF
Global health science: a threat and an opportunity for collaborative clinical science pp1277 - 1279
We will never have a better opportunity to improve public health globally. The question is whether we are shrewd enough, bold enough, and committed enough to make it happen.
Jeremy Farrar
doi:10.1038/ni1532
Full Text | PDF
News and Views Top
IL-10 or not IL-10: that is the question pp1281 - 1283
Four new papers focused on how interleukin 10-producing cells are induced have led to some unexpected and intriguing observations on the nature of interleukin 17-producing T helper cells.
Dragana Jankovic and Giorgio Trinchieri
doi:10.1038/ni1207-1281
Full Text | PDF
See also: Article by Stumhofer et al. | Article by Fitzgerald et al. | Article by Awasthi et al. | Article by McGeachy et al.
CCR5 and its ligands: a new axis of evil? pp1283 - 1285
Many additional effects in HIV pathogenesis are now described for the chemokine receptor CCR5, long recognized as an important coreceptor for HIV, and its ligand CCL3L1.
Michael M Lederman and Scott F Sieg
doi:10.1038/ni1207-1283
Full Text | PDF
See also: Article by Dolan et al.
Competition for cytokines: Treg cells take all pp1285 - 1287
Thymus-derived regulatory T cells are thought to suppress target cells by either a cell contact-dependent mechanism or the production of inhibitory cytokines. A new study suggests a third strategy of apoptosis induced by the consumption of interleukin 2 and other T cell growth factors by regulatory T cells.
Alexander Scheffold, Kenneth M Murphy and Thomas Höfer
doi:10.1038/ni1207-1285
Full Text | PDF
See also: Article by Pandiyan et al.
Macrophage tolerance: CD47-SIRP-α-mediated signals matter
pp1287 - 1289
Inhibition of phagocyte activity depends on the ligation of SIRP-α by CD47. New findings show that Sirpa polymorphisms influence the engraftment and tolerance of xenogeneic transplants in NOD-SCID mice.
Hitoshi Takizawa and Markus G Manz
doi:10.1038/ni1207-1287
Full Text | PDF
See also: Article by Takenaka et al.
Unexpected partnership between IL-15 and DAP10 pp1289 - 1291
Interleukin 15 (IL-15) is essential for natural killer (NK) cell development and function, and the adaptor DAP10 transmits important signals in NK cells. New work shows that IL-15 and DAP10 cross regulate each other.
Francesco Colucci
doi:10.1038/ni1207-1289
Full Text | PDF
See also: Article by Horng et al.
Research Highlights Top
Research Highlights p1293
doi:10.1038/ni1207-1293
Full Text | PDF
Review Top
Finding a way out: lymphocyte egress from lymphoid organs
pp1295 - 1301
Susan R Schwab and Jason G Cyster
doi:10.1038/ni1545
Abstract | Full Text | PDF
Articles Top
'Role reversal' for the receptor PAR1 in sepsis-induced vascular damage pp1303 - 1312
Nicole C Kaneider, Andrew J Leger, Anika Agarwal, Nga Nguyen, George Perides, Claudia Derian, Lidija Covic and Athan Kuliopulos
doi:10.1038/ni1525
Abstract | Full Text | PDF
Polymorphism in Sirpa modulates engraftment of human hematopoietic stem cells pp1313 - 1323
Katsuto Takenaka, Tatiana K Prasolava, Jean C Y Wang, Steven M Mortin-Toth, Sam Khalouei, Olga I Gan, John E Dick and Jayne S Danska
doi:10.1038/ni1527
Abstract | Full Text | PDF
See also: News and Views by Takizawa & Manz
CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms pp1324 - 1336
Matthew J Dolan, Hemant Kulkarni, Jose F Camargo, Weijing He, Alison Smith, Juan-Manuel Anaya, Toshiyuki Miura, Frederick M Hecht, Manju Mamtani, Florencia Pereyra, Vincent Marconi, Andrea Mangano, Luisa Sen, Rosa Bologna, Robert A Clark, Stephanie A Anderson, Judith Delmar, Robert J O'Connell, Andrew Lloyd, Jeffrey Martin, Seema S Ahuja, Brian K Agan, Bruce D Walker, Steven G Deeks and Sunil K Ahuja
doi:10.1038/ni1521
Abstract | Full Text | PDF
See also: News and Views by Lederman & Sieg
Natural killer cell trafficking in vivo requires a dedicated sphingosine
1-phosphate receptor pp1337 - 1344
Thierry Walzer, Laura Chiossone, Julie Chaix, Andrew Calver, Claude Carozzo, Laure Garrigue-Antar, Yannick Jacques, Myriam Baratin, Elena Tomasello and Eric Vivier
doi:10.1038/ni1523
Abstract | Full Text | PDF
NKG2D signaling is coupled to the interleukin 15 receptor signaling pathway pp1345 - 1352
Tiffany Horng, Jelena S Bezbradica and Ruslan Medzhitov
doi:10.1038/ni1524
Abstract | Full Text | PDF
See also: News and Views by Colucci
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells pp1353 - 1362
Pushpa Pandiyan, Lixin Zheng, Satoru Ishihara, Jennifer Reed and Michael J Lenardo
doi:10.1038/ni1536
Abstract | Full Text | PDF
See also: News and Views by Scheffold et al.
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10 pp1363 - 1371
Jason S Stumhofer, Jonathan S Silver, Arian Laurence, Paige M Porrett, Tajie H Harris, Laurence A Turka, Matthias Ernst, Christiaan J M Saris, John J O'Shea and Christopher A Hunter
doi:10.1038/ni1537
Abstract | Full Text | PDF
See also: News and Views by Jankovic & Trinchieri | Article by Fitzgerald et al. | Article by Awasthi et al. | Article by McGeachy et al.
Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells
pp1372 - 1379
Denise C Fitzgerald, Guang-Xian Zhang, Mohamed El-Behi, Zoë Fonseca-Kelly, Hongmei Li, Shuo Yu, Christiaan J Saris, Bruno Gran, Bogoljub Ciric and Abdolmohamad Rostami
doi:10.1038/ni1540
Abstract | Full Text | PDF
See also: News and Views by Jankovic & Trinchieri | Article by Stumhofer et al. | Article by Awasthi et al. | Article by McGeachy et al.
A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells pp1380 - 1389
Amit Awasthi, Yijun Carrier, Jean P S Peron, Estelle Bettelli, Masahito Kamanaka, Richard A Flavell, Vijay K Kuchroo, Mohamed Oukka and Howard L Weiner
doi:10.1038/ni1541
Abstract | Full Text | PDF
See also: News and Views by Jankovic & Trinchieri | Article by Stumhofer et al. | Article by Fitzgerald et al. | Article by McGeachy et al.
TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell-mediated pathology pp1390 - 1397
Mandy J McGeachy, Kristian S Bak-Jensen, Yi Chen, Cristina M Tato, Wendy Blumenschein, Terrill McClanahan and Daniel J Cua
doi:10.1038/ni1539
Abstract | Full Text | PDF
See also: News and Views by Jankovic & Trinchieri | Article by Stumhofer et al. | Article by Fitzgerald et al. | Article by Awasthi et al.
Erratum Top
Erratum: Immune responses to commensal and environmental microbes p1398
Eric G Pamer
doi:10.1038/ni1207-1398a
Full Text | PDF
Corrigendum Top
Corrigendum: Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-γ p1398
Jamie R Schoenborn, Michael O Dorschner, Masayuki Sekimata, Deanna M Santer, Maria Shnyreva, David R Fitzpatrick, John A Stamatoyannopoulos and Christopher B Wilson
doi:10.1038/ni1207-1398b
Full Text | PDF